Meta-analysis of randomized, controlled treatment trials for pediatric obsessive-compulsive disorder
- Forfatter(e)
- Watson, H. J. Rees, C. S.
- År
- 2008
- Tidsskrift
- Journal of Child Psychology & Psychiatry & Allied Disciplines
- Sider
- 489-98
- Kategori(er)
- Angst og engstelighet (inkl. både vansker og lidelse) Tvangsforstyrrelser (OCD)
- Tiltakstype(r)
- Kognitiv atferdsterapi, atferdsterapi og kognitiv terapiAntidepressivaBeroligende medikamenter
- Abstract
OBJECTIVE: To conduct a meta-analysis on randomized, controlled treatment trials of pediatric obsessive-compulsive disorder (OCD).
METHOD: Studies were included if they employed randomized, controlled methodology and treated young people (19 years or under) with OCD. A comprehensive literature search identified 13 RCTs containing 10 pharmacotherapy to control comparisons (N = 1016) and five cognitive-behavioral therapy (CBT) to control comparisons (N = 161).
RESULTS: Random effects modeling yielded statistically significant pooled effect size (ES) estimates for pharmacotherapy (ES = .48, 95% CI = .36 to .61, p < .00001) and CBT (ES = 1.45, 95% CI = .68 to 2.22, p = .002). The results were robust to publication bias.
CONCLUSIONS: This is the first meta-analysis of treatment RCTs for pediatric OCD. CBT and pharmacotherapy were the only treatments effective beyond control in alleviating OCD symptoms. CBT showed a greater ES than pharmacotherapy. Previous meta-analyses that included uncontrolled trials exaggerated the efficacy of both treatments.