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How oppositionality, inattention, and hyperactivity affect response to atomoxetine versus methylphenidate: a pooled meta-analysis

Forfatter(e)
van Wyk, G. W. Hazell, P. L. Kohn, M. R. Granger, R. E. Walton, R. J.
År
2012
DOI
10.1177/1087054710389989
Tidsskrift
Journal of Attention Disorders
Sider
314-24
Kategori(er)
ADHD
Tiltakstype(r)
Sentralstimulerende medikamenter
Abstract

OBJECTIVE: To assess how threshold oppositional defiant disorder (ODD), inattention, and hyperactivity-impulsivity affect the response to atomoxetine versus methylphenidate.

METHOD: Systematic review of randomized controlled trials (RCTs; >6 weeks follow-up). The primary measure was core symptom response->40% reduction in ADHD Rating Scale-IV-Parent Version: investigator administered and scored total or domain subscores, as appropriate.

RESULTS: Data from 1,391 children and adolescents (823 atomoxetine, 568 methylphenidate; 7 RCTs) were meta-analyzed. The mean difference in response rates for patients with ODD was 0.6% (95% confidence interval [CI] = -11.9%-13.1%). The "without ODD" patient group showed significant between-trial heterogeneity (p < .001). Response rate differences for patients meeting the threshold for inattention or hyperactivity-impulsivity were -3.1% (95% CI = -11.5%-5.3%) and -4.9% (95% CI = -14.3%-4.4%), respectively.

CONCLUSIONS: Meeting the threshold criteria for oppositionality, inattention, or hyperactivity-impulsivity did not alter core ADHD symptom response to atomoxetine versus methylphenidate, which was equivalent.