Vitamin D Supplementation is Beneficial for Children with Autism Spectrum Disorder: A Meta-analysis
- Forfatter(e)
- Song, L. Luo, X. Jiang, Q. Chen, Z. Zhou, L. Wang, D. Chen, A.
- År
- 2020
- Tidsskrift
- Clinical Psychopharmacology and Neuroscience
- Sider
- 203-213
- Kategori(er)
- Autismespekter
- Tiltakstype(r)
- Kosttilskudd og ernæring
- Abstract
Objective: We conducted a meta-analysis of randomized controlled trials to explore whether vitamin D supplementation is beneficial for symptom improvement in children with autism spectrum disorder.
Method(s): We systematically searched the PubMed database, EMBASE, Cochrane Library, Web of Science, Sino-Med, Wanfang Data, and China National Knowledge Infrastructure mainly up to September 2019. Using a fixed effects model, we calculated the standard mean difference with 95% confidence interval. Furthermore, we analyzed baseline serum 25-hydroxyvitamin D levels and outcome scores including the Social Responsiveness Scale and Child Autism Rating Scale scores after vitamin D supplementation.
Result(s): There was no significant difference in baseline serum 25-hydroxyvitamin D levels among 203 children included from three studies in the meta-analysis. After vitamin D supplementation, the outcome scores in the experimental group were dramatically elevated compared with those in the control group (p = 0.03).
Conclusion(s): Vitamin D supplementation improves the typical symptoms of autism spectrum disorder, as indicated by reduced Social Responsiveness Scale and Child Autism Rating Scale scores; thus, it is beneficial for children with autism spectrum disorder. Copyright © 2020, Korean College of Neuropsychopharmacology