The Effects of <i>Crocus sativus</i> (Saffron) on ADHD: A Systematic Review
- Forfatter(e)
- Seyedi-Sahebari, S. Farhang, S. Araj-Khodaei, M. Akhondzadeh, S. Naseri, A. Sanaie, S. Frounchi, N.
- År
- 2023
- Tidsskrift
- Journal of Attention Disorders
- Sider
- 11
- Kategori(er)
- ADHD
- Tiltakstype(r)
- Urter
- Abstract
Background and Aim: Crocus sativus also known as saffron, is one of the most popular traditional plants. This study aims to evaluate the efficacy and safety of saffron extracts in ADHD.
Method: This study includes clinical trial studies that assessed the efficacy and/or safety of saffron in ADHD patients. Non-English papers, review articles, commentaries, letters, observational studies, thesis, animal studies, in-vitro studies, and conference abstracts were not included. The risk of bias in randomized studies was evaluated based on the Cochrane RoB.2, and risk of bias in pre-post intervention studies was assessed using the ROBINS-I tool.
Results: Four studies met our inclusion criteria with a total of 118 patients. The results manifested an efficient role of saffron as either an adjuvant therapy to MPH or a single therapy against ADHD, without significant safety issues.Discussion: Saffron demonstrates promise in improving ADHD symptoms, with an acceptable safety profile. Future well-designed multicentral studies are suggested.