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The Effects of <i>Crocus sativus</i> (Saffron) on ADHD: A Systematic Review

Forfatter(e)
Seyedi-Sahebari, S. Farhang, S. Araj-Khodaei, M. Akhondzadeh, S. Naseri, A. Sanaie, S. Frounchi, N.
År
2023
DOI
10.1177/10870547231203176
Tidsskrift
Journal of Attention Disorders
Sider
11
Kategori(er)
ADHD
Tiltakstype(r)
Urter
Abstract

Background and Aim: Crocus sativus also known as saffron, is one of the most popular traditional plants. This study aims to evaluate the efficacy and safety of saffron extracts in ADHD.

Method: This study includes clinical trial studies that assessed the efficacy and/or safety of saffron in ADHD patients. Non-English papers, review articles, commentaries, letters, observational studies, thesis, animal studies, in-vitro studies, and conference abstracts were not included. The risk of bias in randomized studies was evaluated based on the Cochrane RoB.2, and risk of bias in pre-post intervention studies was assessed using the ROBINS-I tool.

Results: Four studies met our inclusion criteria with a total of 118 patients. The results manifested an efficient role of saffron as either an adjuvant therapy to MPH or a single therapy against ADHD, without significant safety issues.Discussion: Saffron demonstrates promise in improving ADHD symptoms, with an acceptable safety profile. Future well-designed multicentral studies are suggested.