Aripiprazole in young people with early psychosis: a systematic review and meta-analysis of weight gain
- Forfatter(e)
- Parmar, A. Hulme, D. Hacking, D. Shymko, G. Dragovic, M. Terina, G. Waters, F.
- År
- 2022
- Tidsskrift
- Australasian Psychiatry
- Sider
- 10398562211037334
- Kategori(er)
- Psykose Bivirkninger/uønskede effekter
- Tiltakstype(r)
- Antipsykotika
- Abstract
OBJECTIVE: Aripiprazole is often prescribed to young people, although there remain unanswered questions about its effects on weight gain. This study undertook a meta-analysis of weight gain occurring in young people with early psychosis who were prescribed aripiprazole.
METHOD: A systematic search was conducted for studies reporting on aripiprazole and weight change in young people with a psychotic disorder. A meta-analysis integrated the data into an estimate of effect size.
RESULTS: Eleven studies met the inclusion criteria amounting to 886 participants (mean age 18 years). The results showed significant weight gain averaging 2.7 kg. These increases were associated with a longer duration of exposure to aripiprazole but not a higher dosage.
CONCLUSIONS: The results highlight the importance of regular patient monitoring and the early implementation of interventions to manage antipsychotic-related weight gain.