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Aripiprazole in young people with early psychosis: a systematic review and meta-analysis of weight gain

Forfatter(e)
Parmar, A. Hulme, D. Hacking, D. Shymko, G. Dragovic, M. Terina, G. Waters, F.
År
2022
DOI
10.1177/10398562211037334
Tidsskrift
Australasian Psychiatry
Sider
10398562211037334
Kategori(er)
Psykose Bivirkninger/uønskede effekter
Tiltakstype(r)
Antipsykotika
Abstract

OBJECTIVE: Aripiprazole is often prescribed to young people, although there remain unanswered questions about its effects on weight gain. This study undertook a meta-analysis of weight gain occurring in young people with early psychosis who were prescribed aripiprazole.

METHOD: A systematic search was conducted for studies reporting on aripiprazole and weight change in young people with a psychotic disorder. A meta-analysis integrated the data into an estimate of effect size.

RESULTS: Eleven studies met the inclusion criteria amounting to 886 participants (mean age 18 years). The results showed significant weight gain averaging 2.7 kg. These increases were associated with a longer duration of exposure to aripiprazole but not a higher dosage.

CONCLUSIONS: The results highlight the importance of regular patient monitoring and the early implementation of interventions to manage antipsychotic-related weight gain.