Treatment of eating disorders: A systematic meta-review of meta-analyses and network meta-analyses
- Forfatter(e)
- Monteleone, A. M. Pellegrino, F. Croatto, G. Carfagno, M. Hilbert, A. Treasure, J. Wade, T. Bulik, C. M. Zipfel, S. Hay, P. Schmidt, U. Castellini, G. Favaro, A. Fernandez-Aranda, F. Il Shin, J. Voderholzer, U. Ricca, V. Moretti, D. Busatta, D. Abbate-Daga, G. Ciullini, F. Cascino, G. Monaco, F. Correll, C. U. Solmi, M.
- År
- 2022
- Tidsskrift
- Neuroscience & Biobehavioral Reviews
- Sider
- 104857
- Kategori(er)
- Spiseforstyrrelser
- Tiltakstype(r)
- FamilieterapiForeldreveiledning/-terapiAntidepressivaSentralstimulerende medikamenter Fysisk aktivitet Selvhjelp
- Abstract
Treatment efficacy for eating disorders (EDs) is modest and guidelines differ. We summarized findings/quality of (network) meta-analyses (N)MA of randomized controlled trials (RCTs) in EDs. Systematic meta-review ((N)MA of RCTs, ED, active/inactive control), using (anorexia or bulimia or eating disorder) AND (meta-analy*) in PubMed/PsycINFO/Cochrane database up to December 15th, 2020. Standardized mean difference, odds/risk ratio vs control were summarized at end of treatment and follow-up. Interventions involving family (family-based therapy, FBT) outperformed active control in adults/adolescents with anorexia nervosa (AN), and in adolescents with bulimia nervosa (BN). In adults with BN, individual cognitive behavioural therapy (CBT)-ED had the broadest efficacy versus active control; also, antidepressants outperformed active. In mixed age groups with binge-eating disorder (BED), psychotherapy, and lisdexamfetamine outperformed active control. Antidepressants, stimulants outperformed placebo, despite lower acceptability, as did CBT-ED versus waitlist/no treatment. Family-based therapy is effective in AN and BN (adolescents). CBT-ED has the largest efficacy in BN (adults), followed by antidepressants, as well as psychotherapy in BED (mixed). Medications have short-term efficacy in BED (adults).