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Does supplementation of choline during or after pregnancies exposed to alcohol improve neurocognitive development of children? A meta-analysis

Forfatter(e)
Lino, G. M., de Carvalho, I. N., de Amorim, V. O. A., Bresani-Salvi, C. C., Luna, V. L. M., Galvao, P. V. M., Conrado, G. A. M.
År
2025
DOI
10.1016/j.pedneo.2025.02.001
Tidsskrift
Pediatrics & Neonatology
Volum
04
Sider
04
Kategori(er)
Kognisjon (hukommelse, oppmerksomhet og eksekutive funksjoner) Rus (alkohol, illegale rusmidler) For tidlig fødsel Psykisk/fysisk funksjonsnedsettelse
Tiltakstype(r)
Kosttilskudd og ernæring
Abstract

BACKGROUND

Alcohol impairs early cognitive development, especially in utero exposures. Nutrient supplementation may avert some of its consequences.

OBJECTIVE

We reviewed whether prenatal and postnatal choline supplementation could improve neurocognitive development in children of alcohol-exposed pregnancies.

METHODS

A systematic literature search was conducted in Medline, Embase, and Cochrane Library databases to identify randomized controlled trials published up to May 01, 2024. Data were analyzed using Standardized Mean Difference (SMD) with 95 % Confidence Intervals (CI) and a random-effects model. Sensitivity analyses and the posterior probability of benefit (Pr) were calculated using a Bayesian Markov chain Monte Carlo model.

RESULTS

Five trials were included in this review. Prenatal supplementation likely benefits memory (SMD 0.61, 95 % CI 0.19 to 1.02; Pr

= 96.29 %; I

= 0 %; 2 trials; 94 participants; moderate-certainty evidence). Postnatal supplementation may improve global cognition (SMD 0.78, 95 % CI 0.21 to 1.34; Pr

= 96.94 %; I

= 13 %; 2 trials; 62 participants; low-certainty evidence) and a small benefit to attention was only demonstrated in the Bayesian analysis (postnatal: SMD 0.44, 95 % CI -0.73 to 1.61; Pr

= 91.80 %; I

= 84 %; 2 trials; 83 participants; low-certainty evidence).

CONCLUSION

Supplementation of choline in either period could benefit neurocognitive development in children of heavy-drinking mothers.

REGISTRATION

CRD42024537733 (PROSPERO).