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Effects of sulforaphane on ABC and SRS scales in patients with autism spectrum disorder: a meta-analysis

Forfatter(e)
Guo, J., Wang, Y., He, W., Lou, M., Peng, Y., Shi, H., Lian, A.
År
2025
DOI
10.1016/j.braindev.2025.104321
Tidsskrift
Brain & Development
Volum
47
Sider
104321
Kategori(er)
Atferdsproblemer, antisosial atferd og atferdsforstyrrelser Autismespekter
Tiltakstype(r)
Kosttilskudd og ernæring
Abstract

Autism spectrum disorder (ASD) has become an increasingly prominent global health issue. Sulforaphane is a phytochemical with multiple functions that target many of the same biochemical and molecular pathways (biomarkers) associated with ASD. This study aimed to conduct a meta-analysis based on sulforaphane's effect on Aberrant Behavior Checklist (ABC) and Social Responsiveness Scale (SRS) in patients with ASD. We conducted comprehensive searches in the PubMed, Medline, Cochrane, EMBASE, and Web of Science databases from their inception. The modified Cochrane risk of bias tool was used to check the risk of bias of the included studies. Review Manager 5.3 software was used to conduct this meta-analysis. The results of this meta-analysis showed that sulforaphane significantly improved irritability and hyperactivity symptoms, suggesting that sulforaphane has the potential for the combined treatment of autism. Additional studies are needed to confirm and explore the effect of sulforaphane.